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. 2001 Apr 3;98(8):4687–4692. doi: 10.1073/pnas.071582498

Figure 1.

Figure 1

Ictal and interictal BOLD responses in human visual cortex. A representative functional MRI slice is shown (A). The slice plane was oriented near-perpendicular to the calcarine fissure, so that cerebellum occupies the lower portion of the figure, and occipital lobe occupies the upper portion. (B–E) Representative BOLD responses over time, taken from single voxels within homologous areas of the occipital lobe (B and D, Right vs. C and E, Left), as designated by green arrows. Time is shown on the x axis, and levels of MR modulation are shown on the y axis. The stimulus-driven signal oscillation in B–E is the BOLD responses to 16-s presentations of the checkerboard visual stimulus (on response), relative to the intervening 16-s presentations of a black screen with a fixation point (off response). (D and E) Normal BOLD modulation during an interictal period for each hemisphere. (B and C) The BOLD responses during a migraine aura affecting only the right hemisphere (B) (see Fig. 2). Perturbations did not appear in the left hemisphere during the ictal (C), or interictal scans (D and E).