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. Author manuscript; available in PMC: 2012 Oct 4.
Published in final edited form as: Biochemistry. 2011 Sep 8;50(39):8392–8406. doi: 10.1021/bi200593m

Figure 4.

Figure 4

Overall structure of ZhuI and a comparison with TcmN ARO/CYC. (A) Left, the ZhuI dimer structure. β-strands at the dimer interface are labeled, and the non-crystallographic 2-fold rotation axis relating the two monomers is in red. Middle, close-up view of the dimer interface. Right, illustration of complementarity and chemical nature of the dimer contact surface; one monomer is represented as electrostatic surface (red = electronegative, blue = electropositive, and grey = neutral) and the other is drawn as cartoon with interacting residues in sticks. (B) Monomer structure of ZhuI with secondary structure elements labeled and two interacting residues (V55 and V138) shown as spheres. (C) The crystal structure of TcmN ARO/CYC with residues P56 and H128 (structurally equivalent to those listed for (B)) drawn as spheres, see the sequence alignment in Figure 4–3B. (C) Backbone overlay of ZhuI and TcmN ARO/CYC