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. Author manuscript; available in PMC: 2012 Apr 5.
Published in final edited form as: Nature. 2011 Oct 5;478(7367):114–118. doi: 10.1038/nature10490

Figure 2. Endog regulates cardiac hypertrophy.

Figure 2

a, Immunoblot of Endog expression in mouse and rat tissues (Endog: ~30 kDa). b, Immunoblot of Endog expression in myocyte and non-myocyte populations isolated from neonatal rat heart. c, Cardiomyocyte size (n≥100 cells, n=3 independent experiments) treated with shRNA against Endog (shEndog) or control shRNA (shControl) in the presence or absence of the hypertrophic stimulant phenylephrine (PE, 100μM, 24 h). d, Expression of the hypertrophic biomarker Anf in shEndog and shControl treated cells. e, Cardiomyocyte size (Supplementary Fig. 5) in Endog-/- and wildtype (WT) mice at baseline and following angiotensin II-induced cardiac hypertrophy. f, LVM/tibial length in Endog-/- and WT mice at baseline and following AngII stimulation. Data are represented as mean+s.e.m. *, P<0.05, **, P<0.01, ***, P<0.001.