Table 2.

Comparison of Secreted Blood Reporter

	SEAP	Soluble peptide	Gluc
Time to complete the assay	hours	hours	minutes
Sensitivity	ng/ml	ng/ml	1,000-fold more than SEAP
Dynamic range to cell number	<3 orders of magnitudes	>4 orders of magnitudes	>5 orders of magnitudes
Assay in the whole blood	No, requires sample processing	No, requires sample processing	Yes
Half-life	3 h leading to accumulation	hours	20 minute
Detected in urine	No	Yes, also in peritoneal fluid	Yes, cleared by kidneys
Localized with in vivo imaging	In situ histology	No	Yes, non-invasive imaging
Immunogenicity	Need species-specific	No	Yes
Tested in clinic	No	Yes	No
Cost	$$	$$$	$