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Partial reactions catalyzed by ecto-nucleoidases: (1) ecto-ATPase, ectonucleoside triphosphate diphosphohydrolase; (2) ecto-5′-nucleotidase; (3) ecto-3′-nucleotidase. The sequential hydrolysis of extracellular ATP by Leishmania ectonucleotidases triggers the host inflammatory and immune response following P2 receptor activation by extracellular ATP (blue square) and P1 (A2) receptors activation by extracellular adenosine nucleoside (yellow square). ADO: Adenosine.
