Table 1.
Biological parameters from OLETF and LETO rats at 27 and 38 weeks of age.
| OLETF (n = 10) |
LETO (n = 10) |
P value | OLETF (n = 10) |
LETO (n = 10) |
P value | |
|---|---|---|---|---|---|---|
| 27 weeks | 38 weeks | |||||
| Body weight (g) | 642 ± 40.9 | 491 ± 34.6 | <0.0001 | 621 ± 69.4 | 580 ± 80.7 | 0.2089 |
| Food intake (g/day) | 34.9 ± 6.1 | 19.1 ± 1.5 | <0.0001 | 39.3 ± 6.1 | 29.7 ± 2.0 | <0.0001 |
| Kidney-to-body weight ratio (%) | 0.703 ± 0.10 | 0.597 ± 0.054 | 0.0091 | 0.780 ± 0.12 | 0.592 ± 0.050 | 0.0008 |
| Fasting plasma glucose (mg/dL) | 183 ± 58.9 | 135 ± 34.2 | 00388 | 248 ± 53.6 | 129 ± 25.3 | <0.0001 |
| Hemoglobin A1c (%) | 4.4 ± 0.85 | 3.3 ± 0.11 | 0.0021 | 5.7 ± 1.2 | 3.3 ± 0.18 | 0.0001 |
| Total cholesterol (mg/dL) | 123 ± 23.1 | 97.4 ± 9.5 | 0.0081 | 153 ± 34.6 | 101 ± 9.37 | 0.0009 |
| Creatinine (mg/dL) | 0.24 ± 0.04 | 0.36 ± 0.04 | <0.0001 | 0.33 ± 0.05 | 0.46 ± 0.1 | 0.0031 |
| Urinary protein-to-creatinine ratio (mg/mg) | 2.73 ± 2.10 (n=5)* |
0.60 ± 0.08 (n=5)* |
<0.0001 | 5.65 ± 2.36 (n=5)* |
0.94 ± 0.38 (n=5)* |
<0.0001 |
Values are expressed as the mean ± SD.
*Urinary specimens were obtained from 5 rats per group to measure urinary protein and creatinine levels.
OLETF: Otsuka Long-Evans Tokushima Fatty, LETO: Long-Evans Tokushima Lean.