Skip to main content
. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Trends Endocrinol Metab. 2011 Jun 28;22(9):364–373. doi: 10.1016/j.tem.2011.05.003

Figure 1. Roles of MafA and MafB in mouse β cells.

Figure 1

MafA and MafB are expressed in a dynamic temporal pattern (top panel)19, 20 and required at distinct stages in mouse β cells (bottom panels). MafB is critical to β cell terminal differentiation through regulation of key β genes (blue). Thus MafB binds and directly initiates the insulin and MafA transcription in developing β cells. In addition, it is required at E18.5 for expression of β cell factors involved in glucose-stimulated insulin secretion (e.g. pdx1, slc2a2, and slc30a8). MafA regulates most of these β cell genes (red) in adult when MafB in silenced.