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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Trends Endocrinol Metab. 2011 Jun 28;22(9):364–373. doi: 10.1016/j.tem.2011.05.003

Figure 2. A cascade of transcription factors plays important roles in pancreas development.

Figure 2

The schematic diagram is a simplified model indicating transcription factors expressed at each stage of rodent pancreas development. The large Maf transcription factors MafB and MafA are located at the bottom of the cascade. MafB is required for the terminal differentiation of α and β cells while MafA is critical for β cell function in adult.