Table 5.
HIF1A-Regulated Genes Showing Differential Expression between 20% and 4% O2 Conditions
| Probe Set ID | Accession | Unigene | Symbol | Descriptions | Fold |
|---|---|---|---|---|---|
| 201848_s_at | NM_004052 | Hs.144873 | BNIP3 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | −4.6 |
| 201010_s_at | NM_006472 | Hs.533977 | TXNIP | Thioredoxin interacting protein | −4.1 |
| 236180_at | W57613 | Hs.419240 | SLC2A3 | Solute carrier family 2 (facilitated glucose transporter), member 3 | −3.2 |
| 202718_at | NM_000597 | Hs.162 | IGFBP2 | Insulin-like growth factor binding protein 2 | −3.1 |
| 202887_s_at | NM_019058 | Hs.523012 | DDIT4 | DNA-damage-inducible transcript 4 | −3.0 |
| 207543_s_at | NM_000917 | Hs.500047 | P4HA1 | Procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha polypeptide I | −2.2 |
| 201105_at | NM_002305 | Hs.227751 | LGALS1 | Lectin, galactoside-binding, soluble, 1 | −2.1 |
| 1562529_s_at | BC040965 | Hs.569497 | RORA | RAR-related orphan receptor A | −2.1 |
| 202022_at | NM_005165 | Hs.155247 | ALDOC | Aldolase C, fructose-bisphosphate | −2.0 |
| 200737_at | NM_000291 | Hs.78771 | PGK1 | Phosphoglycerate kinase 1 | −2.0 |
| 238996_x_at | NM_000034 | Hs.513490 | ALDOA | Aldolase A, fructose-bisphosphate | −1.8 |
| 200650_s_at | NM_005566 | Hs.2795 | LDHA | Lactate dehydrogenase A | −1.7 |
| 203234_at | NM_003364 | Hs.488240 | UPP1 | Uridine phosphorylase 1 | −1.6 |
| 210512_s_at | NM_003376 | Hs.73793 | VEGF | Vascular endothelial growth factor | −1.6 |
| 202627_s_at | NM_000602 | Hs.414795 | SERPINE1 (PAI-1) | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | −1.5 |
| 208308_s_at | NM_000175 | Hs.466471 | GPI | Glucose phosphate isomerase | −1.5 |
| 201251_at | NM_002654 | Hs.534770 | PKM2 | Pyruvate kinase, muscle | −1.5 |
| 200822_x_at | NM_000365 | Hs.524219 | TPI1 | Triosephosphate isomerase 1 | −1.4 |
| 202934_at | NM_000189 | Hs.198427 | HK2 | Hexokinase 2 | −1.4 |
| 217294_s_at | U88968 | Hs.517145 | ENO1 | Enolase 1, (alpha) | −1.3 |
| 209773_s_at | BC001886 | Hs.75319 | RRM2 | Ribonucleotide reductase M2 polypeptide | 1.4 |
Genes in the top panel are positively-regulated by HIF1A and exhibit decreased expression under 20% O2. The gene in the bottom panel, RRM2, has been shown to be repressed HIF1A and are up-regulated in human embryonic stem cells cultured under 20% O2. Fold changes shown are the average of three paired comparisons.