Table 1.

Molecular markers and their functions on chromosome 17.

Gene ID	Name	Location	Functions
2064	ERBB2/HER2	17q21.1	Epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Amplification and/or overexpression have been reported in numerous cancers.
7153	TOP2A	17q21-q22	DNA topoisomerase, controls and alters the topologic states of DNA during transcription. It is associated with the development of drug resistance.
201299	RDM1	17q11.2	RAD52 protein encoded by RDM1 is involved in DNA double-strand break repair and recombination event. Disruption of the RDM1 gene resulted in an increased sensitivity to the anti-cancer drug cisplatin.
7157	P53	17p13.1	P53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair. It is accumulated in a variety of transformed cells.
672	BRCA1	17q21	BRCA1 plays a role in maintaining genomic stability. It acts as a tumor suppressor. BRCA1 combines with other tumor suppressors, to form a BRCA1-associated genome surveillance complex (BASC). Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers.
3090	HIC-1	17p13.3	Hypermethylated in cancer 1, a candidate tumor suppressor gene which undergoes allelic loss in breast and other human cancers. The human HIC-1 gene is a target gene of p53.
4137	TAU	17q21.1	Microtubule-associated protein TAU (MAPT), functions to keep cell shape, microvesicle transportation and spindle formation. Interfering spindle microtubule dynamics will cause cell cycle arrest and apoptosis. TAU detection helps to identify those patients who are most likely to benefit from taxane treatment and resistant to paclitaxel treatment.