Table 2.
Association of SLCO1B1 and SLCO2B1 variants with total and LDL cholesterol in individuals treated with atorvastatin.
| SNP | Basal | Atorvastatin | Change (%) | |||
|---|---|---|---|---|---|---|
| TC | LDL-C | TC | LDL-C | TC | LDL-C | |
| SLCO1B1 | ||||||
| c.521T>C | ||||||
| TT (108) | 281 ± 37 | 192 ± 34 | 199 ± 29 | 118 ± 26 | 28.7 ± 9.1 | 38.1 ± 12.4 |
| TC + CC (28) | 282 ± 35 | 193 ± 31 | 192 ± 32 | 114 ± 28 | 31.8 ± 9.3 | 40.9 ± 11.6 |
| P | 0.890 | 0.942 | 0.253 | 0.442 | 0.171 | 0.433 |
| c.388A>G | ||||||
| GG (49) | 279 ± 32 | 193 ± 36 | 193 ± 29 | 111 ± 25 | 30.6 ± 9.8 | 41.3 ± 12.4 |
| AA + AG (82) | 280 ± 40 | 191 ± 28 | 200 ± 31 | 121 ± 27 | 28.0 ± 9.2 | 36.6 ± 12.1 |
| P | 0.550 | 0.527 | 0.162 | 0.077 | 0.123 | 0.034 |
| c.463C>A | ||||||
| CC (95) | 283 ± 38 | 196 ± 35 | 199 ± 32 | 120 ± 27 | 29.4 ± 9.3 | 38.4 ± 11.5 |
| CA + AA (41) | 271 ± 31 | 184 ± 27 | 194 ± 27 | 113 ± 26 | 27.9 ± 9.9 | 38.0 ± 14.4 |
| P | 0.070 | 0.072 | 0.374 | 0.198 | 0.414 | 0.871 |
| SLCO2B1 | ||||||
| −71T>C | ||||||
| TT (42) | 281 ± 43 | 194 ± 37 | 200 ± 34 | 120 ± 28 | 28.6 ± 8.6 | 37.6 ± 10.6 |
| TC + CC (94) | 282 ± 35 | 198 ± 29 | 198 ± 29 | 116 ± 27 | 29.4 ± 9.4 | 39.0 ± 12.9 |
| P | 0.891 | 0.794 | 0.598 | 0.324 | 0.463 | 0.394 |
Number of individuals is given in parenthesis. Values are mean ± standard deviation. P: p-values as evaluated by one-way analysis of variance, significant p-values are indicated in bold. TC: total cholesterol (mg/dL); LDL-C: low-density lipoprotein cholesterol (mg/dL).