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Genome-wide linkage analysis of (DW-Pou1f1dw/+ × CAST) F2 mice identifies a hearing modifier locus on Chr 2. The 41 dw/dw F2 mice with the most extreme ABR thresholds were analyzed, and LOD scores are shown for the linkage associations of these threshold values with each of 90 chromosomal markers. Only markers on Chr 2 showed statistically significant linkage. The Pou1f1 gene is located on Chr 16.
