Figure 6 .

The Mtap1a allele correlates with, but is neither necessary nor sufficient for, protection of hearing in Pou1f1^dw mice. Two cohorts of dw/dw F₂ (DW/J-Pou1f1^dw/+ × CAST/EiJ) mice, with a total number of 251, were tested for their hearing sensitivity and genotyped for sequence variants of GCTCCA repeats in the Mtap1a gene. Mice were grouped by their Mtap1a genotypes, and we plotted the number of mice with ABR thresholds in each 20-kHz interval. Within each bar, the solid or open portion represents the mice generated at the Jackson laboratory (Jax mice); the hatched portion represents the mice generated at the University of Michigan (UM mice). (A) The numbers of mice homozygous for CAST/EiJ Mtap1a alleles at each ABR threshold interval. (B) The numbers of mice heterozygous for CAST/EiJ and DW/J Mtap1a alleles at each ABR threshold interval. (C) The numbers of mice homozygous for DW/J Mtap1a alleles at each ABR threshold interval.