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(a) Macroscopic appearance and histology of an affected Card11unm mouse, showing pruritic skin lesion and mast cell infiltrates (arrows) revealed by alcian blue staining. (b) Plasma IgE concentrations in αβT cell-sufficient or deficient mice carrying either wild-type or mutant alleles of Card11, quantified by ELISA. (c) Incidence of dermatitis in αβT cell-sufficient or deficient Card11unm mice.
