Figure 1.

Representative 2D DIGE gel of second trimester maternal plasma in pH 4.5 - 5.5 range. Image shown is from Cy2 signal. Spots numbered are those shown to be significantly differentially expressed in DS samples by more than 1.5 fold (p < 0.05) compared with controls. Eight gels were run (DS [n = 8] and Ctl [n = 8]). See Table 1 for mass spectrometry-based identifications. 1 = ceruloplasmin, 2 = inter-alpha-trypsin inhibitor heavy chain H4, 3 = complement C4-A precursor, 4 = complement C5 precursor, 5 = complement component C9 precursor, 6 = kininogen-1, 7 = complement C1s subcomponent precursor