Table 8. Evaluation plasma vs. Ab in the TZMbl pseudovirus assay.
242315-plasma | HJ16 | 314994-plasma | HGN194 | 529552-plasma | HK20 | |||
Tier 1 | MW965.26 | C | 8552 | >50 | 20050 | <0.02 | 22466 | 17.3 |
SF162.LS | B | 2116 | >50 | 1210 | <0.02 | 3529 | >150 | |
BaL.26 | B | 112 | >50 | 109 | 0.10 | 180 | >150 | |
Tier 2 | Q168.a2 | AD | 71 | 0,04 | 347 | >50 | 27 | >150 |
Q769.d22 | A | <20 | >50 | 721 | >50 | <20 | 31.5 | |
Q461.e2 | A | 194 | 0,2 | 58 | >50 | <20 | >150 | |
RHPA4259.7 | B | 831 | <0.02 | <20 | 35.4 | <20 | >150 | |
AC10.0.29 | B | 57 | >50 | 535 | >50 | 26 | >150 | |
Du151.2 | C | 173 | >50 | 61 | >50 | 31 | >150 | |
ZM109F.PB4 | C | 24 | 2.9 | 43 | 2.2 | <20 | >150 | |
96ZM651.2 | C | 132 | 0.20 | 88 | >50 | 42 | >50 | |
T257-31 | CRF02_AG | <20 | 17 | 64 | >50 | <20 | >150 | |
CH110.2 | CRF07_BC | 204 | >50 | <20 | >50 | <20 | >150 | |
CH181.12 | CRF07_BC | 69 | 43.9 | 107 | 49.6 | 40 | >150 |
Plasma were tested at the Beth Israel Deaconess Medical Center with different dilutions starting from 1 in 20, results are shown in ID50 values. Abs were tested at different concentrations starting from 150 µg for their capacity to neutralize HIV-1 PV, results are shown in IC50 values (µg/ml). In bold: plasma ID50 ≥1 in 100, Ab IC50 ≤50 µg (see Mat & Meth).