Figure 1. Young (3 months old) Risp^+/P224S mice have unimpaired physiological performance.

The sex of the mice (F for female, M for male), as well as the type of test, are indicated below each bar. Mice were tested for motor coordination (average of 3 trials after 2 days of training on a Rota-Rod), motor learning (Rota-Rod performance on day 3 relative to day 1), running speed (the maximum speed mice could maintain on a powered treadmill) and male fertility (number of pups sired by Risp ^+/P224S males with wild-type females). All measurements were made in wild-type/heterozygote littermate pairs, and results are expressed as the effect of Risp heterozygosity relative to wild-type within each pair. Sample sizes (number of littermate pairs) are shown superimposed on each bar. Actual (not normalized) values are shown in Table S2.