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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Biomaterials. 2011 Sep 28;32(35):9536–9545. doi: 10.1016/j.biomaterials.2011.08.069

Schematic.

Schematic

HPMA-peptide copolymers used for adenovirus polymer coating (A). Linkers can be nondegradable (Ahx), reducible (AEDP), or enzyme cleavable (AhxFKFLAhx). Negatively charged adenovirus interact with cationic HPMA-oligolysine polymers to form a polymer-coated virus (B).