Table 1.

List of progression of operant behavioral paradigms employed, number of training sessions, and primary psychological construct assessed by each task. The numerator in Number Completing Training ratio indicates how many mice were unable to complete the full number of training sessions, and the denominator the number who began training in that task.

Task	Main Construct(s) Measured	Sessions	Number Completing Training
Fixed Ratio	Simple operant contingency	~3	WT=8/8 Tg2576=7/8
Alternation	Simple response rule learning	~8	WT=8/8 Tg2576=6/7
Light-Dark Discrimination	Simple discrimination	10	WT=8/8 Tg2576=6/6
Chained FR1-FR1-FR1	Completion of a response sequence; behavioral flexibility	5	WT=8/8 Tg2576=6/6
Non-Match to Position	Complex, conditional discrimination; behavioral flexibility	40	WT=8/8 Tg2576=5/6
Delayed NMTP	Short-term (working memory)	28	WT=8/8 Tg2576=3/6
Reaction Time	Motor initiation	15	WT=8/8 Tg2576=2/3
Signal Detection	Sustained attention	10	WT=4/4* Tg2576=3/3#
Progressive Ratio	Reinforcer strength	10	WT=4/4 Tg2576=3/3

WT = wild type mice

^*Randomly discontinued to balance N's

^#one mouse returned after illness