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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Aug 24;21(21):6451–6455. doi: 10.1016/j.bmcl.2011.08.084

Scheme 1.

Scheme 1

Reagents: (a) (R)-3-amino-3-N-Boc-piperidine, NaBH(OAc)3, DCE, 95%; (b) HCl, dioxane, rt, 96%; (c) RCOCl, DIEA, DCM, rt, 65–95%.