Fig. 4.

Effects of iptakalim (Ipt; 0.01, 0.1, and 1 μmol/L) on cell death (a) and LDH release (b) in cultures of primary cerebrocortical neurons, astrocytes, and microvascular endothelial cells under hypoxic conditions

Hypoxic conditions were induced using 0.5 mmol/L Na₂S₂O₄. Glibenclamide (Gli, 1 μmol/L) was added to reverse the effects of iptakalim. Data are presented as mean±SEM of four individual experiments. ^* P<0.05 for cells exposed to hypoxia compared with the normal control group; ^# P<0.05 for cells that treated with iptakalim under hypoxic condition compared with cells treated with hypoxia without iptakalim