Table 3.
Body measurements from animals on control diet or high fat diet prior to the drug intervention.
| High fat diet* | Control diet | ||||||
|---|---|---|---|---|---|---|---|
| H# | I# | L# | |||||
| aCSF | BDNF | aCSF | BDNF | aCSF | BDNF | aCSF | |
| Body weight (g) | 651.0 ± 11.1 | 660.1 ± 16.5 | 595.7 ± 15.9 | 600.3 ± 14.3 | 568.7 ± 14.3 | 565.0 ± 14.5 | 566.0 ± 18.1 |
| Body fat (g) | 164.9 ± 6.0 | 167.3 ± 6.4 | 120.2 ± 2.1 | 120.4 ± 2.3 | 91.1 ± 4.2 | 90.8 ± 4.4 | 85.6 ± 4.9 |
| Lean mass (g) | 412.7 ± 9.0 | 416.1 ± 10.2 | 403.3 ± 12.6 | 408.1 ± 11.2 | 404.7 ± 11.1 | 402.5 ± 10.2 | 407.0 ± 13.0 |
| Relative fat mass (%)Δ | 25.4± 0.9 | 25.3 ± 0.6 | 20.3 ± 0.5 | 20.1 ± 0.4 | 16.0 ± 0.7 | 16.0 ± 0.6 | 15.1 ± 0.7 |
| Relative lean mass (%)¥ | 63.4 ± 0.7 | 67.6 ± 0.4 | 65.0 ± 0.4 | 67.9 ± 0.4 | 71.1 ± 0.7 | 71.3 ± 0.6 | 71.9 ± 0.6 |
: Rats ranked in the top 24, intermediate 24 and lowest 21 based on body fat were assigned to high (H), intermediate (I), and low (L) body fat groups, respectively.
Animals in each group were further subdivided into two subgroups (12 rats/subgroup for H and L group, and 10–11 rats/subgroup for L group; aCSF or BDNF, 1 μg) with body fat level evenly distributed among subgroups. There were no significant differences between aCSF and BDNF subgroups in H, I and L groups. H: high body fat; I: intermediate body fat; L: low body fat. There is no significant difference in any measurements between aCSF and BDNF subgroups in H, I and L groups. H: high body fat; I: intermediate body fat; L: low body fat. There is no significant difference in any measurements between aCSF and BDNF subgroups in H, I and L groups.
Relative fat mass= fat mass/body weight × 100%;
Relative lean mass = lean mass/body weight × 100%.