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Putative membrane-bound SPL. Proposed topology of the membrane-bound mammalian and yeast SPL homodimer.82 StSPL containing a modeled PLP-S1P external aldimine is colored as in Figure 4 and displayed as surface. A: Compared to Figure 4(A), the protein was rotated 90° anticlockwise along an axis parallel to the plane of the sheet such that the putative active site entrance faces the reader. B: The protein is oriented as in Figure 4(A). TMH stands for transmembrane helix.
