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. Author manuscript; available in PMC: 2012 Oct 7.
Published in final edited form as: Mol Cell. 2011 Oct 7;44(1):134–146. doi: 10.1016/j.molcel.2011.06.038

Figure 3. p62 regulates cell size and autophagy.

Figure 3

(A) Cell size was determined in WT and p62KO MEFs deprived of leucine for 24 h and re-stimulated with leucine for 24 h. Error bars specify the standard deviation between three independently performed experiments. *p<0.05. (B) WT and p62KO MEFs were deprived of leucine and serum for 2 and 4 hours in the absence or presence NH4Cl and leupeptin. Cell lysates were analyzed for the levels of the specified proteins. Graphs represent the densitometric LC3-II/actin ratios. (C) Protein extracts from livers of 24h fasted WT and p62KO mice were analyzed for the levels of the specified proteins. These results are representative of three experiments.