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. 2001 Mar 27;98(8):4734–4739. doi: 10.1073/pnas.081553598

Figure 1.

Figure 1

Specific blockade of α7-nAChRs by β-amyloid peptides. (A) ACh responses characteristic of hippocampal α7-nAChRs before (Left), during (Center), and 5 min after (Right) a 3-min exposure to 100 nM rat Aβ1–42. (B) Concentration dependence for the Aβ1–42 blockade of the α7-nAChR response (n = 6–8 for each value). (C) Effects of the rat (r) and human (h) Aβ1–42 and Aβ1–40 peptides (all at 100 nM; n = 8) on the α7-nAChR response. Negative control: hAβ40–1 (100 nM; n = 6); vehicle (n = 6) was extracellular recording solution plus 0.005% acetic acid. Both here and in the other figures, results were normalized to the peak response obtained from the same cell before peptide application (normalized current).