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Noncompetitive blockade of hippocampal α7-nAChRs by Aβ1–42. Individual cells were tested at 10 mM ACh and one or more additional concentrations of ACh before and after application of 10 nM Aβ1–42. Results were normalized to those obtained with 10 mM ACh and then pooled for each data point (n = 5–7). Increasing the concentration of ACh did not overcome the partial block achieved with the concentration of Aβ1–42 used.
