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LINE-1 retrotransposition. (A) Scheme of an RC-L1. In the scheme, ORF1 and ORF2 are represented as yellow and blue rectangles. Within ORF2, the relative position of the EN, RT and cysteine-rich domains (C) is indicated. Also shown are the S and AS promoters in the L1 5′UTR (black thin arrows). (B) Working model of L1 retrotransposition. In the scheme, for simplicity L1 is drawn as a light blue arrow. Details can be found in the main text.
