Table 3.
Characteristics of patients by MTHFD1L genotype (N = 3095).
| Outcome | GG (n = 1366) |
AG (n = 1327) |
AA (n = 402) |
P Value | |
|---|---|---|---|---|---|
| Patient Died | 395 (12.8%) | 137 (10.0%) | 182 (13.7%) | 76 (18.9%) | < 0.001 |
| Time (Year) | 0.120 | ||||
| Mean ± SD | 2.8 ± 1.2 | 2.8 ± 1.1 | 2.7 ± 1.2 | 2.8 ± 1.4 | |
| Median (IQR*) | 2.7 (2.0, 3.6) | 2.8 (2.1, 3.7) | 2.6 (2.0, 3.6) | 2.8 (1.8, 3.6) | |
| Demographics and History | |||||
| Age | 59.3 ± 12.5 | 59.9 ± 12.2 | 59.1 ± 12.8 | 57.9 ± 12.4 | 0.010 |
| Sex | 0.003 | ||||
| Male | 2095 (67.7%) | 944 (69.1%) | 909 (68.5%) | 242 (60.2%) | |
| Female | 1000 (32.3%) | 422 (30.9%) | 418 (31.5%) | 160 (39.8%) | |
| Race Category | < 0.001 | ||||
| White/Caucasian | 2315 (74.9%) | 1189 (87.3%) | 943 (71.1%) | 183 (45.6%) | |
| Black/African American | 607 (19.7%) | 109 (8.0%) | 303 (22.9%) | 195 (48.6%) | |
| Other | 167 (5.4%) | 64 (4.7%) | 80 (6.0%) | 23 (5.7%) | |
| Unknown | 6 | 4 | 1 | 1 | |
*IQR: interquartile range