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Reduced LTP in hippocampal perforant path–dentate gyrus neurons of mice deficient in the DGKɛ. (a) Time course and extent of LTP induction after HFS (arrow) in control and DGKɛ−/− mice. EPSP amplitude was normalized as percent of average baseline EPSP amplitude. (b) Mean potentiation of EPSP calculated by the average EPSP amplitude at 1–5 min, 16–20 min, and 26–30 min after HFS plotted as percent of baseline. Data are mean ± SEM. ∗, P < 0.05; ∗∗, P < 0.01.
