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. Author manuscript; available in PMC: 2011 Oct 22.
Published in final edited form as: Mol Cell. 2010 Oct 22;40(2):323–332. doi: 10.1016/j.molcel.2010.10.004

Figure 3. Metabolically-sensitive protein modifications can participate in cellular nutrient sensing.

Figure 3

Production of acetyl-CoA for acetylation is regulated by ATP-citrate lyase (ACL), in a manner dependent on the availability of mitochondria-derived citrate. Both N-linked glycosylation and O-GlcNAcylation of proteins relies on production of UDP-GlcNAc by the hexosamine biosynthetic pathway.