Table I.
Joint frequency of number of evaluated genes (Y) with number of observed VDJ events (X)a
| total IgH per cell (Y) | Number of VDJ (X) | p-valueb | ||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | total | Fixedc ϑ = 3 |
Sequentiald ϑ = 3 |
Sequentiald ϑ = 4 |
|
| 2 | 2 | 2 | 0 | 0 | 4 | 1.000 | 0.352 | 0.409 |
| 3 | 7 | 0 | 0 | 0 | 7 | 0.033 | 0.186 | 0.114 |
| 4 | 2 | 1 | 1 | 1 | 5 | 0.056 | 0.010 | 0.065 |
| 5 | 0 | 3 | 0 | 0 | 3 | 0.382 | 0.238 | 0.224 |
| 6 | 1 | 3 | 1 | 0 | 5 | 0.904 | 0.954 | 0.947 |
| 7 | 0 | 3 | 3 | 2 | 8 | 0.698 | 0.333 | 0.682 |
| 8 | 0 | 1 | 0 | 2 | 3 | 0.163 | 0.059 | 0.078 |
| 9 | 0 | 0 | 0 | 1 | 1 | 0.497 | 0.189 | 0.289 |
| Total | 12 | 13 | 5 | 6 | 36 | 0.076 | 0.041 | 0.209 |
a
Y is the total number of IgH, GL or rearranged, detected per cell; X includes VDJ (3R), 2R, and 1R.
b
for an exact test of the null hypothesis that data fit the ϑ-VDJ model. Total designates global goodness of fit.
c
Logarithms of the conditional likelihoods (CLs) were computed as CL3,Y : −41.3; CL4,Y : −45.0; CL5,Y : −56.6; CL6,Y : −75.5; CL7,Y : −95.7. Our conditional maximum likelihood estimate (CMLE) of discrete parameter ϑ is 3.
d
Logarithms of the CLs were computed as CL3,Y : −53.6; CL4,Y : −53.0; CL5,Y : −54.0; CL6,Y : −55.0; CL7,Y : −55.6. Our CMLE of ϑ is 4.