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. 2001 Apr 10;98(8):4752–4757. doi: 10.1073/pnas.081074998

Figure 1.

Figure 1

Dividing and newly generated cells in the SZ and OB of adult macaque monkeys as detected by immunoperoxidase staining for BrdU or PCNA. Examples of clusters of BrdU-labeled cells 2 h after the last of five daily injections (a and b) and of PCNA-positive cells (c and d) in coronal sections of the anterior SZ along the striatal wall of the lateral ventricle (LV). (a) Although occasional immunopositive cells initially appeared to be part of the ependymal layer (E), further examination revealed them to be immediately subjacent to it and, thus, to belong to the SZ; no evidence for cell proliferation in the ependymal layer was observed. (e and f) PCNA-positive cells (arrows) among a stream of cells in the SZ closely associated with the basal aspect of the anterolateral ventricle. C, caudate nucleus; S, septal nuclei. Upper left area is dorsal. (f) The boxed field in e at higher magnification, showing that PCNA-positive cells are in the SZ but not the ependyma. (g) A sagittal section of the OB shows “strings” of elongated, PCNA-positive nuclei (arrows) in the white matter (WM) as it enters the core of the OB. GL, granule cell layer. (h and i) BrdU-labeled mitotic figures in the OB 2 h after five daily injections. (h) An early anaphase cell in the glomerular layer. (i) A late anaphase/early telophase cell in the external plexiform layer. [Bars = 20 μm (a–d and f), 100 μm (e), 50 μm (g), and 10 μm (h and i).]