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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Neuropharmacology. 2011 Aug 3;61(8):1256–1264. doi: 10.1016/j.neuropharm.2011.07.025

Table 1.

Physiological parameters following drug administration in unanesthetized rats

Chronic Vehicle
 Chronic Valproate
Saline Quinpirole Saline Quinpirole
Before After Before After Before After Before After
Rectal Temperature (°C) 36.8 ± 0.5 36.7 ± 0.4 36.8 ± 0.3 36.9 ± 0.2 36.9 ± 0.4 37.0 ± 0.3 36.8 ± 0.4 37.0 ± 0.2
Heart Rate (beats/min) 414 ± 26 402 ± 48 409 ± 42 430 ± 30 425 ± 37 434 ± 27 441 ± 31 433 ± 53
Arterial blood pressure
     (mmHg)
     Systolic 178 ± 13 166 ± 7 174 ± 10 181 ± 13 175 ± 10 166 ± 8 162 ± 14 162 ± 11
     Diastolic 109 ± 8 101 ± 7 109 ± 7 103 ± 7 109 ± 6 96 ± 11 102 ± 7 100 ± 6
Orofacial activity duraion (s)
     Orofacial activity 10 ± 2 11 ± 3
     Calm period 17 ± 4 15 ± 3

Values are means ± SD (n= 7) measured before drug injection (quinpirole 1mg/kg, i.v.) and 10 minutes after [14C] AA infusion. Paired t-tests were used to compare means in the same animal before and after drug injection.