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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Neurogastroenterol Motil. 2011 Aug 24;23(11):995–e458. doi: 10.1111/j.1365-2982.2011.01772.x

Figure 1.

Figure 1

Association of TGR5 SNP rs11554825 with small bowel and colonic transit in the overall cohort of patients and healthy controls who underwent transit measurement and, specifically, in patients with IBS-D. A modest overall association is noted between SNP rs11554825 and transit in the entire IBS cohort for Colonic filling at 6 h (CF6, p=0.061) and colonic transit (GC24, p=0.083). The association with CF6 was most pronounced in IBS-D (p=0.017) with the TC/CC subgroup having an average 50% faster small bowel transit time compared to the TT subgroup. In contrast to the numerical difference in CF6 in the TC/CC subgroup compared to TT subgroup in IBS-D, colonic transit in IBS-D patients was not significantly different in the 2 subgroups.