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Binding affinity of R3 peptide substrate and AdoMet with intrinsic fluorescence quenching
| PRMT1 | KD, R3 | Fluorescent quenching | KD, AdoMet | Fluorescent quenching |
|---|---|---|---|---|
| μm | % | μm | % | |
| WT | 5.7 ± 0.52 | 28 ± 1.9 | 4.2 ± 1.5 | 17 ± 0.13 |
| M48A | 3.4 ± 0.32 | 37 ± 1.3 | 7.1 ± 1.8 | 15 ± 0.17 |
| M48L | 2.4 ± 0.29 | 28 ± 1.5 | 7.1 ± 0.94 | 29 ± 4.2 |
| M48F | 4.9 ± 0.38 | 30 ± 1.4 | 4.4 ± 0.93 | 23 ± 3.1 |
| M155A | 3.9 ± 0.53 | 34 ± 1.3 | 3.8 ± 0.87 | 19 ± 2.6 |
