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Tunicamycin inhibits the growth of a triple negative breast tumor. The xenografts were developed in athymic nude mice after injecting MDA-MB-231 (ER−/PR−/EGFR−) human breast cancer cells and treated with tunicamycin (0.25 mg/kg) orally twice a week. A, tumor size in a control xenograft (untreated) and after tunicamycin treatment (TM-treated); B, tumor volume (mm3) as a function of time. ◆---◆, control; ■---■, tunicamycin.
