Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Jun 23;286(33):29388–29396. doi: 10.1074/jbc.M110.192732

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 6. — NO donor decreased IRS-2 protein expression in β-cells. GSNO (300 μm) decreased IRS-2 protein expression in a time-dependent manner in INS-1/832 cells (A). 5-h treatment with GSNO exerted dose-dependent inhibitory effects on IRS-2 expression in INS-1/832 cells (B) and βTC-6 cells (D). Treatment with SNAP (300 μm) for 5 h also resulted in suppressed expression of IRS-2 in INS-1/832 cells (C). IB, immunoblotting. *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus the cells without NO donor. Error bars, S.E.