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Model for MBNL1 binding and excluding exon 5. MBNL1 binds the 90-nucleotide regulatory region in the AGEZ to regulate exon 5 exclusion. By binding within the AGEZ, MBNL1 appears to inhibit the ability of the spliceosome to locate the 3′-ss. The M enclosed in a circle represents MBNL1 proteins binding the pre-mRNA.
