FIGURE 4.

Desipramine does not alter hKv1.5 expression. A, representative hKv1.5 current families recorded under control conditions or after a 6-h exposure to 30 μm desipramine are shown. Currents were elicited using depolarizing voltage steps from −70 to +40 mV. Tail currents were recorded on return to −100 mV. Holding potential was −80 mV. B, quantitative analysis of hKv1.5 current densities measured under control conditions or after incubation with 30 μm desipramine for 3 or 6 h is shown. C, quantitative analysis of hKv1.5 current densities after overnight incubation with 10 or 30 μm desipramine is shown. Data are presented as the mean ± S.E.