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HCR variant -fold change in ganglioside binding compared with wild-type HCR
| Protein | Relative affinitya |
|---|---|
| HCR/FR1111A | 0.13 |
| HCR/FR1256A | 0.04 |
| HCR/FR1111A,R1256A | 0.01 |
| HCR/FH1241K | 65 |
| HCR/FR1111A,H1241K,R1256A | 0.25 |
| HCR/EK1093A | 4 |
| HCR/EK1093R | 1 |
| HCR/EK1215A | |
| HCR/EK1215H | 0.05 |
| HCR/ER1230A | 0.59 |
a Values standardized to the wild-type control for each data set.
