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. 2011 Aug 12;286(39):34457–34467. doi: 10.1074/jbc.M111.229633

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Biochemically detectable Tau pathology in JNPL3 mice is reduced after passive immunization with anti-Tau antibodies. A, AT8 Western blot of the P1 brain fraction from 6-month-old JNPL3 mice shows the specificity of the antibody for the 64-kDa band of hyperphosphorylated human Tau that comigrates with PHF Tau from AD brain (15) and correlates with functional deficits in several models of tauopathy (16). The 64-kDa band is weaker in the MC1 and PHF1 treatment groups compared with control antibody. B, HT7 Western blot of total Tau in total extracts shows no apparent differences between treatment groups.