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S-cone ERG is eliminated in Nrl−/− mice with defective rod and cone PDE6. Light-adapted S-cone responses in controls, Nrl−/− cpfl1/+ rd/+ (A), Nrl−/− cpfl1 rd/+ (A) and in mice lacking rod PDE6β subunit, Nrl−/− cpfl1 rd mice (C). M-cone responses in Nrl−/− cpfl1 rd/+ (B) and Nrl−/− cpfl1 rd (C) and in control, Nrl−/− cpfl1/+ rd/+ mice (B). All recordings were performed using littermate controls at P30 with light intensity of 0.7 log cd s/m2.
