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. 2011 Aug 4;286(38):33037–33044. doi: 10.1074/jbc.M111.257022

FIGURE 5.

FIGURE 5.

Caspase-8 is activated by cytosolic RIG-I-dependent signaling. A, 1080.10 cells were infected with SeV at MOI 10 for the indicated times, and the cell lysates were analyzed for the activation of caspase-8 by Western blot (FL, full-length; CL, cleaved; h.p.i., hours postinfection); B, HT1080 (Wt) or HT1080/RIG-Ic cells (expressing a dominant negative mutant of RIG-I) were transfected with poly(I:C) for the indicated time, and cell lysates were analyzed for the activation of caspase-8 by Western blot (FL, full-length; CL, cleaved caspase-8); C, HT1080 and HT1080/RIG-Ic cells were transfected with poly(I:C), and the cell lysates were analyzed for the induction of P56 by Western blot.