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. 2011 Aug 4;286(38):33037–33044. doi: 10.1074/jbc.M111.257022

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Caspase-8-mediated cleavage of IRF-3 is an intermediate step in its proteasome-mediated degradation. IRF-3 undergoes proteasome-mediated degradation in response to dsRNA-dependent signaling. Stimulation of TLR3 or RIG-I signaling by dsRNA activates caspase-8 by proteolysis of inactive procaspase-8. The activated caspase-8 initiates proteolytic processing of IRF-3, generating an intermediate product. The cleaved IRF-3 is then targeted for poly-ubiquitination en route to further degradation.