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. 2011 Jul 22;286(38):33345–33357. doi: 10.1074/jbc.M111.253252

FIGURE 4.

FIGURE 4.

Overexpression of the zebrafish mll N-terminal 84-amino acid peptide (exon1 plus 2 amino acids of exon2) in embryos caused defects in hematopoiesis similar to that observed in mll morphants. A, alignment of 82 amino acids (exon1) in N terminus of zebrafish mll with its human and mouse orthologs. B, morphology of embryos without injection (control) or injected with mRNA encoding 84 amino acids of mll exon1. C, expression patterns of scl, gata1, and pu.1 in embryos without injection (control) or injected with mRNA of 84-amino acid peptide at 10-somite stage. Panels C1 and C2, scl; panels C3 and C4, gata1; panels C5 and C6, pu.1. D, expression patterns of nkx2.5, pax2a, and myoD. Panels D1 and D2, nkx2.5; and panels D3 and D4, pax2a; and panels D5 and D6, myoD. s, somite.