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. 2011 Aug 9;18(5):379–392. doi: 10.1093/dnares/dsr025

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© The Author 2011. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Distinct regulation of STAT6 targets in different cell types. (A) Fold change of TF genes in response to IL-4 stimulation in Ramos cells (red bar) and BEAS2B cells (blue bar) evaluated by digital TSS-tag counts. TFs were ordered by their fold induction in Ramos cells on the x-axis. (B) Schematic representation of a model for distinct STAT6 activation in Ramos cells (upper panels) and BEAS2B cells (lower panels). Inferred chromatin status and pol II binding are shown for the active targets in the left panel and for the silent targets in the right panel. Green circles, STAT6; purple circles, pol II; yellow and orange circles, putative additional factors in Ramos and BEAS2B cells, respectively; left and right columns, active and silent chromatin, respectively.