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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Future Med Chem. 2011 Sep;3(12):1523–1537. doi: 10.4155/fmc.11.88

Figure 3. Overview of tau quality control by molecular chaperones.

Figure 3

From the microtubule-bound pool, tau might be released in a form that is capable of re-binding microtubule (termed ‘cycling tau’). Alternatively, hyperphosphorylated and aggregation-prone tau might accumulate. Chaperones are involved in all stages of cycling tau, in mediating phosphorylation and in making triage decisions.

BAG: Bcl2-associated anthanogene; CHIP: C-terminal Hsp70 interacting protein; FKBP51: FK506-binding protein 51 kDa; Hsp: Heat shock protein.