Figure 4. Decreased expression of SOD2 increases mononuclear phagocyte-induced O2− production.
The production of O2− in WT and Sod2+/− RPE cells exposed to control medium (control), IFN-γ (RPE/IFN-γ), unstimulated mononuclear phagocytes (RPE/Mϕ), or IFN-γ-activated mononuclear phagocytes (RPE/Mϕ/IFN-γ). *P < 0.05, **P < 0.01, ***P < 0.001, compared with WT; ###P < 0.001, compared with its own control.