TABLE 1.
Cholesterol biosynthetic genes bound by Egr1 in response to insulin
| Gene name(s) | Symbol | ChIP-chip binding |
|---|---|---|
| HMG-CoA synthase | Hmgcs | + |
| HMG-CoA reductase | Hmgcr | + |
| Phosphomevalonate kinase | Pmvk | - |
| Mevalonate diphosphate decarboxylase | Mvd | − |
| Isopentenyl diphosphate isomerase | Idi1 | − |
| Farnesyl diphosphate synthase | Fdps | + |
| Farnesyl diphosphate farnesyltransferase 1 | Fdft1 | + |
| Squalene Epoxidase | Sqle | + |
| Lanosterol synthase/lanosterol cyclase | Lss | + |
| Lanosterol 14α demethylase | Cyp51 | + |
| NAD(P)-dependent steroid dehydrogenase-like/NAD(P)H steroid dehydrogenase | Nsdhl | + |
| Sterol C5-desaturase | Sc5d | − |
| 7-Dehydrocholesterol reductase | Dhcr7 | − |
| Malic enzyme | Me1/Mod1 | + |