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. 2011 Jul 7;286(34):29575–29583. doi: 10.1074/jbc.M111.268235

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Extending the RNA PPT primer by more than 18 DNA residues sensitizes the NNTIs while decreasing the potency of the NNRTIs. A, diagram of the chimeric primer/template substrates. B, time course of the different chimeric primer/template substrates. C, compound potency was established for each chimeric primer using the optimal reaction time derived from the time-course experiment showed in B (DNA PPT and RNA PPT+24D = 5 min; RNA PPT, RNA PPT+12D, and RNA PPT+18D = 30 min). D, -fold change in potency of RT inhibitors (IC₅₀ using the chimeric primer/IC₅₀ using the pure RNA PPT primer) upon addition of DNA residues at the 3′-end of the RNA PPT primer.